If you’re craving a bold, creamy, flavor-packed pasta that feels indulgent yet easy enough for a weeknight dinner, Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is the recipe you need in your life. This dish combines tender Cajun-seasoned chicken, perfectly cooked spaghetti, and a luscious garlic mozzarella sauce that clings to every strand of pasta. It’s comforting, spicy, cheesy, and undeniably satisfying.

This recipe draws inspiration from Southern Cajun flavors while embracing classic creamy pasta techniques. The result? A restaurant-style dish you can confidently make at home—no complicated steps, no fancy equipment, just real ingredients and big flavor.

Why You’ll Love This Creamy Cajun Chicken Spaghetti

This isn’t just another pasta recipe. It’s one of those meals that becomes a repeat favorite after the first bite.

Bold Cajun Flavor: Smoky, slightly spicy seasoning brings warmth without overpowering.
Ultra-Creamy Sauce: Garlic, butter, cream, and mozzarella create a silky, rich texture.
Family-Friendly: Easy to adjust the spice level.
Perfect for Any Occasion: Weeknight dinner, date night, or casual entertaining.
One-Pan Friendly: Minimal cleanup with maximum payoff.

The Magic of Cajun Seasoning in Pasta

Cajun seasoning traditionally blends paprika, garlic powder, onion powder, cayenne, oregano, and thyme. When paired with cream and cheese, those spices mellow and deepen rather than burn, creating a balanced, crave-worthy flavor profile.

In this dish, the Cajun seasoning coats the chicken, forming a flavorful crust when seared. Those browned bits then infuse the sauce, making every bite rich and complex.

Ingredients

Spaghetti pasta
Boneless, skinless chicken breast
Cajun seasoning
Olive oil
Unsalted butter
Garlic cloves, minced
Heavy cream
Chicken broth
Shredded mozzarella cheese
Grated parmesan cheese
Paprika
Salt
Black pepper
Red pepper flakes (optional)
Fresh parsley for garnish

Instructions

Bring a large pot of salted water to a boil and cook spaghetti according to package instructions until al dente. Reserve ½ cup pasta water, then drain and set aside.
Slice chicken breasts into thin strips. Season generously with Cajun seasoning, paprika, salt, and black pepper.
Heat olive oil in a large skillet over medium-high heat. Add chicken and cook for 4–5 minutes per side until golden brown and fully cooked. Remove chicken from skillet and set aside.
Reduce heat to medium. Add butter to the same skillet and allow it to melt.
Add minced garlic and sauté for 30–40 seconds until fragrant, being careful not to burn.
Pour in chicken broth and scrape up any browned bits from the bottom of the pan.
Add heavy cream and bring to a gentle simmer.
Stir in mozzarella and parmesan cheese gradually, stirring constantly until smooth and creamy.
Taste and adjust seasoning with salt, pepper, or extra Cajun seasoning if desired.
Add cooked spaghetti to the sauce, tossing to coat evenly. Use reserved pasta water if needed to loosen the sauce.
Return chicken to the skillet and toss everything together until heated through.
Garnish with fresh parsley and optional red pepper flakes. Serve immediately.

Garlic Mozzarella Sauce: What Makes It Special

Unlike traditional Alfredo, this sauce relies heavily on mozzarella for a stretchier, silkier finish. Garlic adds aromatic depth, while chicken broth lightens the creaminess just enough to keep the sauce from feeling heavy.

The result is a sauce that coats rather than overwhelms—luxurious without being greasy.

Tips for Perfect Cajun Chicken Pasta

Don’t Overcook the Chicken: Thin slices cook fast—remove once golden.
Grate Cheese Fresh: Pre-shredded cheese doesn’t melt as smoothly.
Control the Heat: Cajun seasoning varies by brand—start moderate.
Use Pasta Water Wisely: A splash brings everything together beautifully.

Variations to Try

Shrimp Cajun Spaghetti: Swap chicken for shrimp.
Smoked Sausage Version: Adds extra Southern flair.
Low-Carb Option: Use zucchini noodles.
Extra Cheesy Bake: Transfer to a dish, top with mozzarella, and broil.

Serving Suggestions

Serve this dish with:

Garlic bread or cheesy breadsticks
A crisp green salad with lemon vinaigrette
Roasted vegetables like broccoli or asparagus

Storage & Reheating

Refrigerator: Store up to 3 days in an airtight container.
Reheat: Gently on stovetop with a splash of milk or cream.
Not Freezer-Friendly: Cream sauces can separate.

Final Thoughts

Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is the kind of recipe that delivers comfort, flavor, and satisfaction in every bite. It’s bold without being overwhelming, creamy without being heavy, and simple enough to become part of your regular dinner rotation.

Once you make it, don’t be surprised if it becomes your signature pasta dish.